Purine derivative compounds for medical use

摘要

The present invention relates to a compound of formula (I):
wherein A is N or CH; B is N O, or S; R 1 is H, a (C 1 -C 4 )alkyl group, a methyl(C 1 -C 6 )cycloalkyl group or a (C 1 -C 6 )cycloalkyl group; R 2 is an aryl, an arylmethyl group or a methylheteroaryl group such as methylpyridine and methylthiophene; R 3 is absent when B is O or S, or is H or a (C 1 -C 4 )alkyl group when B is N; R 4 is a (C 1 -C 5 )alkyl group or a (C 1 -C 4 )cycloalkyl group, each group bearing a carboxylic acid group, and said (C 1 -C 5 )alkyl group or (C 1 -C 4 )cycloalkyl being optionally substituted by a hydroxyl group, a halogen group or a methoxy group, and when B is N, R 3 and R 4 can together form a 5- or 6-membered heterocycle substituted by a carboxylic acid group, and optionally substituted by a halogen atom, a hydroxyl group, a methoxy group or a hydroxymethyl group, or anyone of its pharmaceutically acceptable salt, for use in the treatment of a disease characterized by a reduction in macrophage-mediated bacterial killing. The present invention further relates to a few compounds which are new to the corresponding pharmaceutical composition for the same use.