Methods of treating medical conditions by transvascular neuromodulation of the autonomic nervous system

摘要

The present invention is directed to a method for treating a gastrointestinal condition by transvascular neuromodulation of a target site of the autonomic nervous system and preferably a target site in communication with a sympathetic nerve chain. A method for treating a gastrointestinal condition via transvascular neuromodulation incorporating a closed-loop feedback system is also provided.

主权项

1. A method for treating an endocrinological condition in a subject, the method comprising the steps of:
inserting a therapy delivery device, comprising an electrode, into a vein or artery of the subject; advancing the therapy delivery device in the artery or vein to a point adjacent a cervical ganglion of the sympathetic nervous system (SNS) that innervates a component of the endocrine system, such that, upon activation, the therapy delivery device delivers an electrical signal to the cervical ganglion of the SNS; and activating the electrode to deliver an electrical signal to the cervical ganglion of the SNS to treat the endocrinological condition.