| 发明名称 | Anti-DLL3 antibody drug conjugates for treating cancer | ||
| 摘要 | Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided. | ||
| 申请公布号 | US9107961(B2) | 申请公布日期 | 2015.08.18 |
| 申请号 | US201414466941 | 申请日期 | 2014.08.22 |
| 申请人 | Stemcentrx, Inc. | 发明人 | Stull Robert A.;Saunders Laura;Dylla Scott J.;Foord Orit;Liu David;Torgov Michael;Shao Hui |
| 分类号 | A61K39/395;C07K16/18;C12P21/08;A61K47/48;C07K16/28;C07K16/30;A61K31/5517;G01N33/574;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Womble Carlyle Sandridge & Rice, LLP | 代理人 | Womble Carlyle Sandridge & Rice, LLP |
| 主权项 | 1. A method of treating cancer in a subject, the method comprising administering to the subject a therapeutically effective amount of an anti-DLL3 antibody drug conjugate (ADC), or a pharmaceutically acceptable salt thereof, wherein the antibody drug conjugate (ADC) comprises the formula M-[L-D]n, wherein: M comprises an anti-DLL3 antibody; L comprises a linker; D comprises a pyrrolobenzodiazepine (PBD); and n is an integer from 1 to 20. | ||
| 地址 | South San Francisco CA US | ||