| 发明名称 | Heterocyclic inhibitors of necroptosis | ||
| 摘要 | The invention features a series of heterocyclic derivatives that inhibit tumor necrosis factor alpha (TNF-α) induced necroptosis. The heterocyclic compounds of the invention are described by Formulas (I) and (Ia)-(Ie) and are shown to inhibit TNF-α induced necroptosis in FADD-deficient variant of human Jurkat T cells. The invention further features pharmaceutical compositions featuring the compounds of the invention. The compounds and compositions of the invention may also be used to treat disorders where necroptosis is likely to play a substantial role. | ||
| 申请公布号 | US9108955(B2) | 申请公布日期 | 2015.08.18 |
| 申请号 | US201414152703 | 申请日期 | 2014.01.10 |
| 申请人 | President and Fellows of Harvard College;Tufts University;The Brigham and Women's Hospital, Inc.;Trustees of Boston University | 发明人 | Cuny Gregory D.;Teng Xin;Yuan Junying;Degterev Alexei;Porco, Jr. John A. |
| 分类号 | C07D285/06;C07D417/12;C07D207/34;C07D241/24;C07D263/34;C07D277/56;C07D307/84;C07D333/38;C07D231/14;C07D307/68 | 主分类号 | C07D285/06 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Bieker-Brady Kristina;Clark & Elbing LLP |
| 主权项 | 1. The compound | ||
| 地址 | Cambridge MA US | ||