3′,5′-cyclic phosphoramidate prodrugs for HCV infection

摘要

Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents.

主权项

1. A compound of Formula I:or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form, or polymorphic form thereof, wherein:
X is alkoxyl, hydrogen, or hydroxyl; Y is hydroxyl, acetoxyl, or fluoro; Z is substituted alkyl; LC(O)O(L)pC(R)3, -LOC(O)(L)pC(R)3, -LC(O)O(L)pCy, -L-S—S-(LpC(R)3, -LSC(O)(L)pC(R)3, L-S—S-(L)pC(R)3, or -LSC(O)(L)pC(R)3; each L is independently unsubstituted alkylene or substituted alkylene; Cy is unsubstituted cycloalkyl; and p is 0 or 1; and R is hydrogen, alkyl, substituted alkyl, unsubstituted cycloalkyl, unsubstituted aryl, substituted aryl, or heteroaryl.