Cyclic ether DGAT1 inhibitorscyclic ether DGAT1 inhibitors

摘要

The invention relates to compounds of formula (I): useful for treating disorders mediated by acyl coA-diacylglycerol acyl transferase 1 (DGAT1), e.g. metabolic disorders. The invention also provides methods of treating such disorders, and compounds and compositions etc. for their treatment.;

主权项

1. A compound according to formula (I) or a salt or solvate thereof: wherein X is O or CH2; Y is O or CH2; wherein one of X and Y is O and the other is CH2; Z1, Z2, Z3 and Z4 are each, independently, N or CH; L is C(O) or absent; and A is a substituted oxazole, thiazole, oxadiazole or thiadiazole substituted with at least one C1-6alkyl, C3-7cycloalkyl or C1-6haloalkyl.