| 主权项 |
1. A compound of Formula (Ia), or a pharmaceutically acceptable salt, or N-oxide thereof: wherein, ring A is pyridinyl; m is 1, 2, 3 or 4; each RA is independently halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R10, —S(═O)2R10, —N(R11)S(═O)2R10, —S(═O)2N(R9)2, —C(═O)R10, —OC(═O)R10, —CO2R9, —N(R9)2, —C(═O)N(R9)2, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6fluoroalkoxy, C1-C6alkoxy, or C1-C6heteroalkyl; both R1 are taken together with the carbon atom to which they are attached to form a C3-C6cycloalkyl; X is S or O; ring B is phenyl; n is 1, or 2; each R4 is independently hydrogen, halogen, —CN, —NO2, —OH, —OR9, —SR9, —S(═O)R10, —S(═O)2R10, —N(R11)S(═O)2R10, —S(═O)2N(R9)2, —C(═O)R10, —OC(═O)R10, —CO2R9, —OCO2R10, —N(R9)2, —C(═O)N(R9)2, —OC(═O)N(R9)2, —NR11C(═O)N(R9)2, —NR11C(═O)R10, —NR11C(═O)OR10, C1-C6alkyl, C1-C6fluoroalkyl, C1-C6fluoroalkoxy, or C1-C6alkoxy; R5 is -L1-L2-R6; and (i) L1 is —O—, —S—, —S(═O)—, —S(═O)2—, —NH—, —N(CH3)—; —C(═O)—, —C(═O)NH—, —NHC(═O)—, —NHC(═O)O—, —NHC(═O)NH—, —C(═O)O—, —OC(═O)—OC(═O)O—, —OC(═O)NH—, —NHS(═O)2—, or —S(═O)2NH—; and (ii) L2 is C1-C6alkylene, C1-C6fluoroalkylene or C1-C6heteroalkylene; or R5 is L1-R7; and L1 is —O—, —S—, —S(O)—, —S(O)2—, —C(═O)—, —C(═O)NH—, —NHC(═O)—, —NHC(═O)O—, —NHC(═O)NH—, —C(═O)O—, —OC(═O)—, —OC(═O)O—, —OC(═O)NH—, —NHS(═O)2—, or —S(═O)2NH—; R6 and R7 are independently optionally substituted piperidinyl; said optional substituents including at least one of alkyl, fluoroalkyl, —CN, halo, —C(O)—O—(C1-6 alkyl), —CH2—C(O)—O—(C1-6 alkyl), —NH2, —NH(CH3), —N(CH3)2, —OH, —CO2H, —C(O)NH2, —C(O)NH(alkyl), —C(O)N(alkyl)2, alkoxy, fluoroalkoxy, -(alkyl)sulfonyl, -(alkylene)-OH, or —C(O)-(alkyl); each R9 is independently H, C1-C6alkyl, or C1-C6fluoroalkyl; R10 is C1-C6alkyl; and R11 is independently H or C1-C4alkyl. |
