Ets2 and Mesp1 generate cardiac progenitors from fibroblasts

摘要

A method for modulating cell differentiation capabilities using heterologous gene expression. Some embodiments of the invention relate to a method for inducing a cardiac progenitor cell by delivering a reprogramming factor to the cell, wherein the reprogramming factor comprises ETS2 or a combination of ETS2 and Mesp1.

主权项

1. An ETS2 treated cell obtained by a method comprising the step of transducing a somatic cell with ETS2 to produce an artificially increased first level of an ETS2 protein in the somatic cell; wherein the artificially increased first level of ETS2 protein transforms the somatic cell into the ETS2 treated cell having surface marker protein levels of SSEA-3 or Tra-1-81 higher than those found in the somatic cell, wherein the somatic cell is a normal human dermal fibroblast cell.