Hyaluronate compositions

摘要

The present invention provides compositions suitable for topical administration to a mammalian subject including sodium hyaluronate and a pharmaceutically acceptable excipient. The present invention also provides methods for making and using the same.

主权项

1. A composition suitable for topical administration to a mammalian subject, the composition comprising, by mass, from about 0.05% to about 5% sodium hyaluronate and a pharmaceutically acceptable excipient, wherein from about 0.001 wt % to about 5 wt % of the sodium hyaluronate in the composition has a molecular weight ranging between about 0.01 megadaltons and about 0.4 megadaltons; at least 50 wt % of the sodium hyaluronate in the composition has a molecular weight ranging between about 1.65 and 4.0 megadaltons and less than about 0.001 wt % of the sodium hyaluronate in the composition has a molecular weight above about 4.0 megadaltons;
and wherein the pharmaceutically acceptable excipient is predominantly in the liquid phase at ambient temperature.