Implantable device for controlled dissolution and diffusion of low solubility drug

摘要

Implantable drug delivery devices are provided that are deformable between a relatively straightened shape suitable for deployment and a retention shape suited to retain the device within the bladder or other body cavity. While in the body cavity, the devices release drug from solid drug units housed in the devices. The devices are designed to house the solid drug units in a way that exposes one or more sides of the solid drug units to the fluid at the in vivo site of deployment. Methods for using the devices for administering drug and making the devices also are provided.

主权项

1. An implantable drug delivery device comprising:
a drug housing portion which comprises
at least one solid drug unit comprising a drug, andat least one housing having at least one defined opening, wherein the at least one solid drug unit is located within the defined opening such that the housing encases a first portion of the surface of the at least one solid drug unit and exposes a second portion of the surface of the at least one solid drug unit, wherein the device is elastically deformable between a relatively straightened shape suited for insertion through a lumen into a body cavity of a patient and a retention shape suited to retain the device within the body cavity, and wherein release of the drug from the device is controlled by erosion of the exposed second portion of the surface of the at least one solid drug unit.