Device for in vivo delivery of bioactive agents and method of manufacture thereof

摘要

The present invention consists of an implantable structural element for in vivo controlled delivery of bioactive active agents to a situs in a body. The implantable structural element may be configured as an implantable prosthesis, such as an endoluminal stent, cardiac valve, osteal implant or the like, which serves a dual function of being prosthetic and a carrier for a bioactive agent. Control over elution of the bioactive agents occurs through a plurality of cantilever-like cover members which prevent drug elution until an endogenous or exogenous stimulus causes the cover members to open and permit drug elution.

主权项

1. An implantable drug-eluting medical device, comprising a first stent member having a plurality of wall surfaces defining a z-axis thickness of the first stent member to form the implantable drug-eluting medical device, at least a first internal chamber enclosed entirely within the z-axis thickness of the first stent member, at least a first of a plurality of openings communicating between the first internal chamber and at least a first of the plurality of wall surfaces and through a portion of the z-axis thickness of the first stent member, a first bioactive agent disposed within the first internal chamber, and a plurality of metal cover members disposed upon the first of the plurality of wall surfaces, at least a first of the plurality of metal cover members associated with the first opening, each of the plurality of metal cover members having a first position which covers and occludes an associated one of the plurality of openings and a second position which uncovers said associated opening, wherein one of shape memory properties or superelastic properties of the plurality of metal cover members actuate the plurality of metal cover members to pivot between the first position and the second position upon encountering a defined stimulus, and wherein in the second position each of the plurality of metal cover members projects outwardly from the first stent member.