Ligands that bind TGF-β receptor RII

摘要

The disclosure provides an anti-TGFbetaRII immunoglobulin single variable domain. The disclosure also provides a polypeptide, ligand or pharmaceutical composition for treating a disease associated with TGFbeta signaling and a disease selected from the group of: tissue fibrosis, such as pulmonary fibrosis, including idiopathic pulmonary fibrosis, liver fibrosis, including cirrhosis and chronic hepatitis, rheumatoid arthritis, ocular disorders, or fibrosis of the skin, including keloid of skin, and kidney such as nephritis, kidney fibrosis and nephrosclerosis, and a vascular condition, such as restenosis.

主权项

1. An isolated polypeptide comprising an amino acid sequence at least 90% identical to SEQ ID NO: 10, wherein the polypeptide binds TGFbetaRII with a Kd in the range of 10 pM to 50 nM.