| 发明名称 |
Process for the preparation of an orexin receptor antagonist |
| 摘要 |
The present invention is directed to processes for preparing a diazepane compound which is an antagonist of orexin receptors, and which is useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The present invention is further directed to crystalline forms of this diazepane compound and pharmaceutical compositions thereof. |
| 申请公布号 |
US9108959(B2) |
申请公布日期 |
2015.08.18 |
| 申请号 |
US201214002221 |
申请日期 |
2012.02.27 |
| 申请人 |
Merck Sharp & Dohme Corp.;Merck Sharp & Dohme Limited |
发明人 |
Baxter Carl A.;Cleator Edward;Sheen Faye;Krska Shane W.;Stewart Gavin;Strotman Neil;Wallace Debra J.;Wright Timothy |
| 分类号 |
A61K31/551;C07D413/04;C07D413/14;C07D249/06;A61K31/55 |
主分类号 |
A61K31/551 |
| 代理机构 |
|
代理人 |
Thies J. Eric;Todaro John C. |
| 主权项 |
1. A process for preparing a compound of the formula I: or a pharmaceutically acceptable salt thereof,which comprises:contacting a compound of the formula II:with an activating agent to form an acid chloride,followed by contacting the acid chloride with a compound of the formula III: or a salt thereof,in the presence of a weak base to give the compound of the formula I, or a pharmaceutically acceptable salt thereof. |
| 地址 |
Rahway NJ US |
