| 发明名称 | Methods of diagnosing and treating fibrosis | ||
| 摘要 | The present invention is directed to methods of diagnosing and treating a fibrotic condition in a mammalian subject. These methods involve measuring the levels of trimethylation at lysine residue 27 of histone-3 and/or measuring the expression levels of EZH2 or YY-1. Agents useful for treating fibrosis or a fibrotic condition are also disclosed. | ||
| 申请公布号 | US9107942(B2) | 申请公布日期 | 2015.08.18 |
| 申请号 | US200913126875 | 申请日期 | 2009.11.02 |
| 申请人 | University of Rochester | 发明人 | Guo Jia;Lin Xin;Georas Steve;Sime Patricia |
| 分类号 | A61K45/00;A61K31/7088;A61K39/395;C12Q1/68 | 主分类号 | A61K45/00 |
| 代理机构 | LeClairRyan, a Professional Corporation | 代理人 | LeClairRyan, a Professional Corporation |
| 主权项 | 1. A method of treating a subject having a pulmonary fibrotic condition, said method comprising: administering to the subject an agent that inhibits or reduces trimethylation at lysine residue 27 of histone-3 under conditions effective to treat a pulmonary fibrotic condition in the subject, wherein the agent is an EZH2 inhibitor. | ||
| 地址 | Rochester NY US | ||