Use of semaphorin 6A for promoting myelination and oligodendrocyte differentiation

摘要

The invention provides methods of treating diseases, disorsers or injuries involving demyelination and dysmyelination, including multiple sclerosis, by the administration of a Sema6A polypeptide.

主权项

1. A method for promoting proliferation, differentiation, or survival of oligodendrocytes to a mammal in need thereof, comprising administering to the mammal an effective amount of a composition comprising an isolated mammalian semaphorin 6A (“Sema6A”) polypeptide, which comprises amino acids 56 to 472 of SEQ ID NO: 2, wherein the administering is via intraocular, intrathecal, subdural, intracerebroventricular, intracranial or intralesional administration or is an administration directly into the central nervous system and wherein the administering promotes proliferation, differentiation, or survival of oligodendrocytes to the mammal.