| 发明名称 |
Pneumococcal polysaccharide conjugate vaccine |
| 摘要 |
The present invention is in the field of pneumococcal capsular saccharide conjugate vaccines. Specifically, a multivalent Streptococcus pneumoniae immunogenic composition is provided with various conjugated capsular saccharides from different S. pneumoniae serotypes conjugated to 2 or more different carrier proteins, where the composition comprises serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT) or CRM197, optionally wherein 19F is the only saccharide in the composition conjugated to diphtheria toxoid (DT) or CRM197. |
| 申请公布号 |
US9107872(B2) |
申请公布日期 |
2015.08.18 |
| 申请号 |
US200912570266 |
申请日期 |
2009.09.30 |
| 申请人 |
GlaxoSmithKline Biologicals S.A. |
发明人 |
Biemans Ralph Leon;Garcon Nathalie Marie-Josephe;Hermand Philippe Vincent;Poolman Jan;Van Mechelen Marcelle Paulette |
| 分类号 |
A61K39/09;A61K39/00;A61K39/385 |
主分类号 |
A61K39/09 |
| 代理机构 |
|
代理人 |
Carter Barbara J. |
| 主权项 |
1. A Streptococcus pneumoniae immunogenic composition comprising 10 or more capsular saccharides from at least 10 different S. pneumoniae serotypes, each capsular saccharide conjugated to a carrier protein, wherein the composition comprises at least three different carrier proteins, wherein the composition comprises: serotype 19F capsular saccharide conjugated to diphtheria toxoid (DT); serotype 18C capsular saccharide conjugated to tetanus toxoid (TT); and serotype 1, 4, 5, 6B, 7F, 9V, 14 and 23F capsular saccharide conjugated to protein D from Haemophilus influenzae. |
| 地址 |
Rixensart BE |
