Water insoluble polymer: indigestible water-soluble polysaccharide film coatings for colon targeting

摘要

A controlled release pharmaceutical dosage form for controlled release of an active ingredient, includes an active ingredient coated by a polymeric mixture of: at least a water insoluble polymer; and at least an indigestible water-soluble oligosaccharide. The use and method of making the same are also described.

主权项

1. A controlled release delivery dosage form for controlled release of an active ingredient in the colon of patients, comprising an active ingredient coated by a polymeric mixture of:
(i) ethyl cellulose, and (ii) at least an indigestible maltodextrin or at least an indigestible dextrin having between 15 and 35% of 1→6 glucoside linkages, a reducing sugar content of less than 20%, a polymolecularity index of less than 5 and a number-average molecular mass Mn at most equal to 4500 g/mol, said controlled release delivery dosage form comprising a core, the active ingredient being dispersed or dissolved in said core, wherein the indigestible maltodextrin or indigestible dextrin: ethyl cellulose ratio is between 1:2 and 1:8.