Microbial-derived chondroitin sulfate

摘要

Described is chondroitin sulfate obtained from microbial sources, and related compositions and methods.

主权项

1. A method for producing a chondroitin sulfate-like compound, comprising
(a) incubating a microbial culture in culture medium at a culturing temperature of from about 10° C. to about 50° C., wherein said microbial culture comprises a bacterium from a genus selected from the group consisting of Corynebacterium, Microbacterium, Micrococcus, Streptomycetes, Bacillus and Lactobacillus; and (b) purifying said culture medium to obtain a chondroitin sulfate-like compound that includes an N-acetyl-galactosamine group that contains a sulfate group at one or more positions wherein the chondroitin sulfate-like compound is made by the bacteria in the microbial culture, wherein said purifying comprises a method selected from the group consisting of centrifugation of said culture to remove microbial cells from said culture medium, filtration of said culture medium, chromatography of said culture medium, and alcohol precipitation of said culture medium.