| 发明名称 | Recombinant poxvirus expressing homologous genes inserted | ||
| 摘要 | The present invention relates to a recombinant poxvirus vector capable of expressing two or more homologous, foreign sequences, which derive from different variants of a microorganism, and which have a homology of 50% or above. The invention further relates to a method for preparing such recombinant poxvirus and the use of such recombinant poxvirus as medicament or vaccine. Additionally, a method for affecting preferably inducing, an immune response in a living animal, including a human, is provided. | ||
| 申请公布号 | US9109233(B2) | 申请公布日期 | 2015.08.18 |
| 申请号 | US200711985510 | 申请日期 | 2007.11.15 |
| 申请人 | BAVARIAN NORDIC A/S | 发明人 | Howley Paul;Leyrer Sonja |
| 分类号 | C12N15/86;C07K14/005;A61K39/00 | 主分类号 | C12N15/86 |
| 代理机构 | Law Office of Salvatore Arrigo and Scott, Lee, LLP | 代理人 | Law Office of Salvatore Arrigo and Scott, Lee, LLP |
| 主权项 | 1. A recombinant MVA comprising at least two foreign genes of greater than 300 nucleotides which are 50-75% homologous in comparison to each other, wherein each of the foreign genes is stably inserted into a different site in the MVA genome. | ||
| 地址 | Kvistgaard DK | ||