Dual variable domain immunoglobulins and uses thereof

摘要

The present invention relates to engineered multivalent and multispecific binding proteins, methods of making, and specifically to their uses in the prevention, diagnosis, and/or treatment of disease.

主权项

1. A binding protein comprising first and second polypeptide chains, each independently comprising VD1-(X1)n-VD2-C-(X2)n, wherein
VD1 is a first variable domain; VD2 is a second variable domain; C is a constant domain; X1 is a linker; X2 is an Fc region; n is 0 or 1, wherein the VD1 domains on the first and second polypeptide chains form a first functional target binding site and the VD2 domains on the first and second polypeptide chains form a second functional target binding site, and wherein the binding protein is capable of binding Tumor Necrosis Factor a (TNF-α) and Receptor for Advanced Glycation Endproducts (RAGE), wherein the first and second polypeptide chains of the binding protein comprise: a. SEQ ID NO: 154 and SEQ ID NO: 155, or b. SEQ ID NO: 156 and SEQ ID NO: 157.