| 发明名称 |
Method for manufacturing of ciclesonide |
| 摘要 |
The invention relates to a process for preparing the corticosteroid ciclesonide, used for the treatment of respiratory complaints, in epimerically pure form of formula 1:; |
| 申请公布号 |
US9109005(B2) |
申请公布日期 |
2015.08.18 |
| 申请号 |
US201313767902 |
申请日期 |
2013.02.15 |
| 申请人 |
Boehringer Ingelheim International GmbH |
发明人 |
Puder Carsten;Merten Joern;Schmitt Heinz-Peter;Thumerer Markus;Weyell Bjoern |
| 分类号 |
C07J71/00 |
主分类号 |
C07J71/00 |
| 代理机构 |
|
代理人 |
Morris Michael P.;Devlin Mary-Ellen M. |
| 主权项 |
1. A process for preparing ciclesonide of formula 1, characterized in that a compound of formula 2 wherein R1 is Br, is reacted with a salt of formula wherein X+ denotes alkali metal ions or N(R2)4+, wherein R2 denotes C1-6-alkyl and further characterized in that the compound of formula 2 is prepared by a regioselective bromination of a compound of formula 3 |
| 地址 |
Ingelheim am Rhein DE |
