Human arginase and pegylated human arginase and the use thereof

摘要

The present invention provides a site-directed mutated arginase and the preparation method thereof, and the use of said site-directed mutated arginase in preparing a medicament for treating an arginase-related disease. The present invention also provides a pegylated arginase and the preparation method thereof, and the use of said pegylated arginase in preparing a medicament for treating an arginase-related disease.

主权项

1. An arginase, wherein said arginase is human arginase I comprising an amino acid sequence of SEQ ID NO:1 comprising a mutation at position 45 of said SEQ ID NO:1; wherein said mutation is from cysteine to alanine;
wherein said arginase has activity.