Analog compounds of analgesic peptides derived from the venom of <i>crotalus durissus terrificus</i> snakes, their uses, compositions, methods of preparation and purification

摘要

The present invention refers to analog compounds of peptides having the amino acid sequences SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3 or SEQ ID NO: 4, including analgesic peptides derived from snakes of species such as Crotalus durissus terrificus; their uses in the treatment, diagnosis and prevention of painful conditions or mediated by opioid receptors, their pharmaceutical compositions and their methods of preparation and purification, including their uses in the identification of analgesic compounds.

主权项

1. A purified peptide comprising the amino acid sequence: Xaa-Phe-Ser-Pro-Glu-Asn-Cys-Gln-Gly-Glu-Ser-Lys-Pro-Cys (SEQ ID NO:3), wherein Xaa is pyroglutamate; and wherein the cysteine residues in positions 7 and 14 are linked by an intramolecular disulfide bridge; or a salt thereof, wherein the peptide is capable of causing analgesia in a subject.