Silver nanoparticle antimicrobial coating for long-term and short-term infection resistance

摘要

Disclosed herein is an implantable medical device including an antimicrobial layer. The antimicrobial layer may include a first distinct size of silver nanoparticles, a second distinct size of silver nanoparticles, and a third distinct size of silver nanoparticles. The antimicrobial layer extends over a surface of the implantable medical device, and, in some instances, the surface of the implantable medical device may serve as a substrate on which the antimicrobial layer is deposited.

主权项

1. A method of applying antimicrobial protection to an implantable medical device, the method comprising;
applying an antimicrobial layer to a surface of the implantable medical device, the antimicrobial layer comprising multiple distinct sizes of silver nanoparticles; wherein the multiple distinct sizes of silver nanoparticles comprises a first, second and third distinct sizes of silver nanoparticles, wherein the third distinct size of silver nanoparticles includes silver nanoparticles with a diameter of between approximately 1.5 times and approximately 2 times the diameter of the silver nanoparticles of the second distinct size of silver nanoparticles, the second distinct size of silver nanoparticles including silver nanoparticles with a diameter of approximately 2 times the diameter of the silver nanoparticles of the first distinct size of silver nanoparticles.