Silver/polydiguanide complex, preparation method thereof, and antibacterial composition containing the same as an active ingredient

摘要

The present invention relates to a silver/polydiguanide complex and derivatives thereof including silver and polydiguanide having at least two biguanide moieties, wherein the silver is stabilized in an oxidation state of an integer of 0 to 4, a mole ratio between the silver and the polydiguanide is 1:1-4, an average particle diameter of the complex is micrometer or nanometer, and zeta potential of the complex is greater than or equal to zero, a preparation method thereof, and an antibacterial composition for burns or wounds treatment including the same as an active ingredient. A silver/polydiguanide complex according to the present invention is different from conventional silver/polydiguanide complexes in carbon, hydrogen, and nitrogen contents as well as in structure of silver and polydiguanide, and solubility, is a material that exhibits a very good antibacterial activity due to a much lower minimal inhibitory concentration (MIC) value by 10 to 100 folds or more compared to silver sulfadiazine which is a conventional therapeutic agent for burns, and may be usefully used as an antibacterial composition for burns or wounds treatment.

主权项

1. A nanocrystalline silver/polydiguanide complex comprising silver and polydiguanide, wherein the silver and the polydiguanide forms the nanocrystalline silver/polydiguanide complex, which is stabilized in an oxidation state of an integer of 1 to 4, a mole ratio between the silver and the polydiguanide is 1:1-4, an average particle diameter of the nanocrystalline silver/polydiguanide complex is ranging from 1 nm to 200 nm, and a zeta potential of the nanocrystalline silver/polydiguanide complex greater than or equal to zero.