Active agents and their oligomers and polymers

摘要

Conjugates comprising at least two active agents linked by a diglycolic acid or polyglycol diacid linker are disclosed. The invention also concerns oligomers and polymers of these conjugates and their use in therapeutic and industrial applications for localized, immediate or fast release delivery of an active agent, such as an anti-microbial, anti-infective, or antiseptic agent.

主权项

1. A compound according to formula (I): wherein R1 is selected from the group consisting of —[(CH2)xO]y(CH2)z—, —(CH2)y—, —[CH═CH—O]y(CH2)z—, —[(CH═CH—CH2—O]y(CH2)z—, —[CH2—CH═CH—O]y(CH2)z—, —[(CH2)xO]y(CH═CH)—,
wherein w is 1 or 2,x is 2 or 3, andy is equal to an integer from 1 to 10, from 1 to 4, or from 1 to 3,z is equal to 1 or 2, andthe carbon atoms of R1 may be optionally substituted with substituents selected from the group consisting of C1 to C12 alkyl, C1 to C12 alkoxy, C3 to C12 cycloalkyl, C3 to C12 cycloalkoxy, C1 to C12 alkanoyl, C1 to C12 alkanoyloxy, C1 to C12 alkoxy carbonyl, C1 to C12 alkylthio, azido, cyano, nitro, fluoro, chloro, bromo, iodo, hydroxy, oxo, carboxy, aryl, aryloxy, heteroaryl, and heteroaryloxy; each X is the same or different and is selected from the group consisting of —O—, —NR2—, —S—, —SO—, and —SO2—,
wherein R2 is an alkyl group of 1 to 12 carbon atoms.