| 发明名称 | HER-3 antibodies and methods of use | ||
| 摘要 | The invention provides methods of measuring and/or quantifying the presence and/or amount of Her-3 and/or Her-3 in a complex in a sample. The invention also provides antibodies specific for Her-3. | ||
| 申请公布号 | US9110066(B2) | 申请公布日期 | 2015.08.18 |
| 申请号 | US201213670508 | 申请日期 | 2012.11.07 |
| 申请人 | Laboratory Corporation of America Holdings | 发明人 | Bates Michael;Cook Jennifer W.;Diedrich Gundo;Goodman Laurie;Mukherjee Ali;Parry Gordon;Sperinde Jeff;Williams Stephen J. |
| 分类号 | C07K16/00;C12P21/08;G01N33/53;G01N33/574;C07K16/28;C07K16/32 | 主分类号 | C07K16/00 |
| 代理机构 | Kilpatrick Townsend & Stockton LLP | 代理人 | Kilpatrick Townsend & Stockton LLP |
| 主权项 | 1. A monoclonal Her-3 antibody comprising (a) a light chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs: 13, 14 and 15, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs: 16, 17 and 18, respectively, or a monoclonal Her-3 antibody comprising (a) a light chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs: 19, 20 and 21, respectively, and (b) a heavy chain variable region comprising CDR1, CDR2 and CDR3 having sequences as set forth in SEQ ID NOs: 22, 23 and 24, respectively. | ||
| 地址 | Burlington NC US | ||