| 发明名称 | MicroRNA as a cancer progression predictor and its use for treating cancer | ||
| 摘要 | The present invention is based on the findings that a novel function for miR142-3p in the regulation of Sox2, adenylyl cyclase 9 (AC9), and CD133 expressions, and consequently the overall stemness of recurrent GBM cells as well as CSCs, and that miR142-3p modulated tumor-initiating properties in recurrent GBM. The present invention consequently supports the development of novel miRNA-based strategies for brain tumor treatment. | ||
| 申请公布号 | US9107934(B2) | 申请公布日期 | 2015.08.18 |
| 申请号 | US201213725586 | 申请日期 | 2012.12.21 |
| 申请人 | Taipei Veterans General Hospital | 发明人 | Chiou Shih-Hwa;Chiou Guang-Yuh |
| 分类号 | A61K48/00;C07H21/02;C07H21/04;C12N15/63;A61K31/7088;C12N15/113 | 主分类号 | A61K48/00 |
| 代理机构 | Volpe and Koenig, P.C. | 代理人 | Volpe and Koenig, P.C. |
| 主权项 | 1. A method for treating glioblastoma multiforme in a subject, comprising administering a therapeutically effective amount of miR142-3p to the subject in need thereof. | ||
| 地址 | Taipei TW | ||