SHUTTLE VECTOR COMPRISING A PROMOTER INDUCIBLY EXPRESSED UNDER BILE ACID AND COMPOSITION COMPRISING THE SAME

摘要

The present invention relates to a shuttle vector including a promoter in which an expression is induced by a bile acid and a composition including the same. More specifically, the present invention relates to a shuttle vector manufactured by connecting a promoter in which expression is induced by a bile acid from a genome of a lactobacillusjohnsonii PF01 strain, and a lactobacillus plasmid separated from lactobacillussalvarius CPM-7, with a colon bacillus-derived vector. According to the present invention, the shuttle vector including a promoter in which expression is induced by a bile acid and the composition including the same have a feature to be expressed by being specifically reacted to the bile acid existing in an intestine of an animal, thereby enabling a human or an animal to specifically express a useful gene in the intestine. In addition, the useful gene can be used as an oral vaccine transporter as well as a backbone vector for probiotics development having a new function.