El compuesto trans-clomifeno en forma particulada, con un tamaño medio de particula de menos de 30 micras, y al menos 90% de las particulas tienen un tamaño de menos de 50 micras; formulacion que lo comprende, util para el tratamiento de hipogonadismo secundario o diabetes tipo 2 en un varon o para el tratamiento de la infertilidad y el cancer de mama en una mujer, entre otras enfermedades.

摘要

The present invention provides iraws-clomiphene and pharmaceutically acceptable salts and solvates thereof, characterized in that trans-clomiphene is in particulate form having a specific size range. The invention is also directed to pharmaceutical compositions comprising or formulated using trans-clomiphene or pharmaceutically acceptable salts and solvates having a specified size range and their use in treating disorders including secondary hypogonadism, type 2 diabetes, elevated cholesterol, elevated triglycerides, wasting, lipodystrophy, female and male infertility, benign prostate hypertrophy, prostate cancer, breast cancer, ovarian cancer and endometrial cancer.