NOVEL PHARMACEUTICAL FORMULATIONS

摘要

There is provided inter alia a dry powder pharmaceutical formulation for inhalation comprising: (i) 6 (2 ((4 amino 3 (3 hydroxyphenyl) 1 H pyrazolo[3 4 d]pyrimidin 1 yl) methyl) 3 (2 chlorobenzyl) 4 oxo 3 4 dihydroquinazolin 5 yl) N N bis(2 methoxyethyl)hex 5 ynamide or a pharmaceutically acceptable salt thereof including all stereoisomers tautomers and isotopic derivatives thereof and solvates thereof in particulate form as active ingredient; (ii) particulate lactose as carrier; and (iii) a particulate stabilizing agent selected from metal salts of stearic acid such as magnesium stearate and metal salts of stearyl fumarate.