发明名称 |
IMPROVED ASSEMBLY OF BISPECIFIC ANTIBODIES |
摘要 |
<p>Described herein are methods for the efficient production of a heteromultimeric protein, such as a bispecific antibody. Heteromultimeric proteins may be capable of specifically binding to more than one target molecule or different epitopes on a single target molecule. The methods modulate parameters to improve assembly of the heteromultimeric proteins at higher yield and efficiency than otherwise possible. Also described are compositions comprising a hinge-containing polypeptide, such as a half-antibody.</p> |
申请公布号 |
HK1200844(A1) |
申请公布日期 |
2015.08.14 |
申请号 |
HK20150101182 |
申请日期 |
2015.02.04 |
申请人 |
F. HOFFMANN-LA ROCHE AG |
发明人 |
GIESE, GLEN;PERSSON, JOSEFINE;WILLIAMS, AMBROSE;LIM, AMY;SCHEER, JUSTIN |
分类号 |
C07K |
主分类号 |
C07K |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|