SYSTEM AND METHOD FOR USING GENETIC DATA TO DETERMINE INTRA-TUMOR HETEROGENEITY

摘要

The present invention discloses systems and methods for measuring intra-tumor heterogeneity based on genetic information of a tumor. Such systems and methods may indentify genetic information of mutation specific to the tumor, determine a mutant-allele fraction for each mutated locus, calculate mutant-allele tumor heterogeneity (MATH), and measure the distribution of mutant-allele fractions among tumor-specific mutated loci of the tumor.

主权项

1. A computer system for measuring intra-tumor heterogeneity, the computer system programmed to:
a. obtain genetic information of a tumor, b. indentify genetic information of mutation specific to the tumor, c. determine a mutant-allele fraction for each mutated locus, d. calculate mutant-allele tumor heterogeneity (MATH) and measure a distribution of mutant-allele fractions among tumor-specific mutated loci of the tumor, and e. generate report of intra-tumor heterogeneity for the tumor.