Low/High Dose Probiotic Supplements And Methods Of Their Use

摘要

Methods and compositions are hereby disclosed for reducing the numbers of E. coli O157:H7, Salmonella or other pathogens in an animal. The methods include administering to the animal a lactic acid producing bacterium at a relatively low dosage in combination with a lactate utilizing bacterium, followed by administration of the lactic acid producing bacterium at a relatively high dosage. The disclosed methods help achieve pre-harvest food safety and enhance feed performance while keeping the total cost relatively low. The preferred lactic acid producing bacterium is Lactobacillus acidophilus/animalis and the preferred lactate utilizing bacterium is Propionibacterium freudenreichii.

主权项

1. A method for reducing the numbers of pathogens in an animal, said method comprising:
(a) administering to said animal at least one lactic acid producing bacterium and at least one lactate utilizing bacterium for at least 30 days, wherein said lactic acid producing bacterium is administered to said animal at a dosage of between 1×105 and 5×107 CFU per day, and said lactate utilizing bacterium is administered to said animal at a dosage of between 5×108 and 5×109 CFU per day; and (b) administering to said animal at least one lactic acid producing bacterium and at least one lactate utilizing bacterium for at least 20 days, wherein said lactic acid producing bacterium is administered to said animal at a dosage of between 5×108 and 5×109 CFU per day, and said lactate utilizing bacterium is administered to said animal at a dosage of between 5×108 and 5×109 CFU per day, wherein step (a) precedes step (b).