发明名称 |
ANTI-METALLOPROTEASE ANTIBODY FOR DIAGNOSIS AND TREATMENT OF CANCERS |
摘要 |
Expression of proteolytically active, high molecular weight ADAM protease is relatively increased in tumour cells that also express the putative tumour stem cell marker CD133. An antibody or antibody fragment such as 8C7 monoclonal antibody may be used to selectively bind to proteolytically active, high molecular weight AD AMI 0 protease to thereby detect tumour cells and also as a therapeutic agent for treating cancers, tumours and other malignancies inclusive of leukemia, lymphoma, lung cancer, colon cancer, adenoma, neuroblastoma, brain tumour, renal tumour, prostate cancer, sarcoma and/or melanoma. |
申请公布号 |
WO2015117199(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
WO2015AU50036 |
申请日期 |
2015.02.04 |
申请人 |
MONASH UNIVERSITY;MEMORIAL SLOAN-KETTERING CANCER CENTRE;LUDWIG INSTITUTE FOR CANCER RESEARCH LTD |
发明人 |
LACKMANN, MARTIN;JANES, PETER W.;MUDIYANSELAGE, LAKMALI ATAPATTU;SCOTT, ANDREW M.;NIKOLOV, DIMITAR B.;SAHA, NAYANENDU |
分类号 |
G01N33/53;C07K16/28;C07K16/40 |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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