发明名称 |
TRIFUNCTIONAL T CELL-ANTIGEN COUPLER AND METHODS AND USES THEREOF |
摘要 |
A trifunctional molecule comprising a target-specific ligand, a ligand that binds a protein associated with the TCR complex and a T cell receptor signaling domain polypeptide is provided. Engineering T cells with this novel receptor engenders antigen specific activation of numerous T cell functions, including cytokine production, degranulation and cytolysis. |
申请公布号 |
CA2945486(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
CA20152945486 |
申请日期 |
2015.02.06 |
申请人 |
MCMASTER UNIVERSITY |
发明人 |
BRAMSON, JONATHAN;HELSEN, CHRISTOPHER W.;DENISOVA, GALINA;GIRI, RAJANISH;MWAWASI, KENNETH ANTHONY |
分类号 |
C12N15/62;A61K35/17;A61P35/00;C07K14/725;C07K16/00;C07K16/28;C07K19/00;C12N5/10;C12N15/85 |
主分类号 |
C12N15/62 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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