PHARMACEUTICAL SOLUTION, PROCESS OF PREPARATION AND THERAPEUTIC USE

摘要

PROBLEM TO BE SOLVED: To provide liquid oral formulations of 2-oxo-1-pyrrolidine derivatives.SOLUTION: Aqueous solutions of 2-oxo-1-pyrrolidine derivatives are partially unstable in stability storage tests, and degradation products are formed in solutions by basic or acid hydrolysis. However, it has been found that these degradation products are not formed at pH values set between 4.5 and 6.5.