THERAPEUTIC USES OF GLUTATHIONE MIMICS

摘要

A prodrug having antioxidant activity, including a phosphorylated compound having a thiol group. A method of treating oxidative stress by administering a prodrug of a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug, and treating oxidative stress. A method of increasing bioavailability of a thiol compound by creating a prodrug by phosphorylating a thiol compound, administering the prodrug, preventing first pass metabolism of the prodrug, removing a phosphate group from the prodrug, and providing active drug to a site in need of therapy from oxidative stress. A method of preventing radiation damage to healthy tissue by administering a prodrug comprising a phosphorylated compound including a thiol group, removing a phosphate group of the prodrug to provide active drug, and preventing radiation damage to healthy tissue.

主权项

1. A method of treating oxidative stress in a patient, said method comprising the step of administering to the patient a prodrug having antioxidant activity, wherein the prodrug comprises a phosphorylated cysteine of the formula wherein R′ is selected from the group consisting of H and amide groups, and wherein R is selected from the group consisting of H, alkyl groups, and esters; and wherein oxidative stress in the patient is reduced.