OLIGOMERIZATION DOMAIN OF P53 TO BYPASS THE DOMINANT-NEGATIVE EFFECT OF MUTANT

摘要

Disclosed are peptides comprising a partial p53 peptide and a mutated Bcr coiled-coil domain. Also disclosed are nucleic acid sequences capable of encoding a peptide comprising a partial p53 peptide and a mutated Bcr coiled-coil domain. The disclosed peptides and nucleic acid sequences can be used to treat cancer, suppress tumor activity and induce apoptosis.