发明名称 |
MODULATION OF THE IMMUNE RESPONSE |
摘要 |
Described herein are compositions and methods for the modulation of T-cell tolerance, which can be upregulated or down regulated by concurrent enhancement or inhibition of CEACAM1/TIM3 interactions. As described herein, the discovery that CEACAM1 is a direct ligand of TIM3 and vice versa has been shown in cis and in trans. In addition, as demonstrated herein, CEACAM1 and TIM3 are co-regulated during the course of T-cell activation. |
申请公布号 |
US2015225457(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
US201314418726 |
申请日期 |
2013.07.30 |
申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
Blumberg Richard S.;Kuchroo Vijay K.;Huang Yu-Hwa;Zhu Chen;Anderson Ana C. |
分类号 |
C07K7/08;A61K38/10;A61K39/395;C07K14/705 |
主分类号 |
C07K7/08 |
代理机构 |
|
代理人 |
|
主权项 |
1. (canceled) |
地址 |
Boston MA US |