| 发明名称 |
METHODS FOR THE PREPARATION OF HYDROMORPHONE |
| 摘要 |
The present application relates to methods for the preparation of morphine derivatives. In particular, the present application relates to methods for the preparation of hydromorphone from oripavine and oripavine from thebaine. |
| 申请公布号 |
US2015225419(A1) |
申请公布日期 |
2015.08.13 |
| 申请号 |
US201514615892 |
申请日期 |
2015.02.06 |
| 申请人 |
HUDLICKY Tomas;ENDOMA-ARIAS Mary Ann;MURPHY Brennan Augusta;SNAJDR Ivan;MACHARA Ales |
发明人 |
HUDLICKY Tomas;ENDOMA-ARIAS Mary Ann;MURPHY Brennan Augusta;SNAJDR Ivan;MACHARA Ales |
| 分类号 |
C07D495/18;C07F15/02;C07D489/02 |
主分类号 |
C07D495/18 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for the preparation of hydromorphone, comprising:
(a) protecting oripavine under conditions to provide a ketal of Formula I: (b) reducing the ketal of Formula I under conditions to provide a ketal of Formula II:and
(c) deprotecting the ketal of Formula II under conditions to provide hydromorphone, wherein R1, together with the oxygen atoms to which it is bonded, forms a hydrolysable cyclic protecting group. |
| 地址 |
St. Catharines CA |
