INHIBITION OF DIACYLGLYCEROL KINASE TO AUGMENT ADOPTIVE T CELL TRANSFER

摘要

The present invention provides compositions and methods for inhibiting one or more diacylglycerol kinase (DGK) isoform in a cell in order to enhance the cytolytic activity of the cell. In one embodiment, the cells may be used in adoptive T cell transfer. For example, in some embodiments, the cell is modified to express a chimeric antigen receptor (CAR). Inhibition of DGK in T cells used in adoptive T cell transfer increases cytolytic activity of the T cells and thus may be used in the treatment of a variety of conditions, including cancer, infection, and immune disorders.

主权项

1. A composition for enhancing the cytolytic activity of a cell, said composition comprising an inhibitor of diacylglycerol kinase (DGK) or a downstream effector protein thereof.