发明名称 A SOLID FORM OF TAPENTADOL MALEATE AND A METHOD OF ITS PREPARATION
摘要 <p>The present solution relates to tapentadol maleate Form A of formula I, exhibiting the following characteristic reflections in an X-ray powder diffraction pattern, measured with the use of CuKa radiation: 10.7; 11.6; 16.0; 17.1; 20.4; 24.2 and 25.9 ± 0.2° 2-theta, the main onset temperature of 90.0°C when measured with the use of Differential Scanning Calorimetry (DSC), and the absorption peaks at 3217, 2971, 2874, 1705, 1619, 1587, 1534, 1484, 1351, 1250, 1188 a 1075 cm-1 in the IR spectrum.</p>
申请公布号 WO2015117576(A1) 申请公布日期 2015.08.13
申请号 WO2015CZ00011 申请日期 2015.01.30
申请人 ZENTIVA, K.S. 发明人 CERNY, JOSEF;DAMMER, ONDREJ;PEKAREK, TOMAS;CALTA, PAVEL
分类号 C07C215/54;A61K31/135;A61P29/00;C07C57/145 主分类号 C07C215/54
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