发明名称 TABLET FORMULATION FOR CGRP-ACTIVE COMPOUNDS
摘要 The present invention is directed to compositions comprising an extrudate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "Ra" is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.
申请公布号 WO2015119848(A1) 申请公布日期 2015.08.13
申请号 WO2015US13672 申请日期 2015.01.30
申请人 MERCK SHARP & DOHME CORP.;JOHNSON, MARY ANN;ALLAIN, LEONARDO RESENDE;EICKHOFF, W. MARK;IKEDA, CRAIG, B.;BROWN, CHAD, D.;FLANAGAN, FRANCIS, J., JR.;NOFSINGER, REBECCA;MAROTA, MELANIE;LUPTON, LISA;PATEL, PARESH, B.;XI, HANMI;XU, WEI 发明人 JOHNSON, MARY ANN;ALLAIN, LEONARDO RESENDE;EICKHOFF, W. MARK;IKEDA, CRAIG, B.;BROWN, CHAD, D.;FLANAGAN, FRANCIS, J., JR.;NOFSINGER, REBECCA;MAROTA, MELANIE;LUPTON, LISA;PATEL, PARESH, B.;XI, HANMI;XU, WEI
分类号 C07D221/02;A61K9/26;A61K31/437 主分类号 C07D221/02
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