发明名称 |
METHODS OF TREATMENT OF ISCHEMIA-INDUCED ANGIOGENESIS AND ARTERIOGENESIS |
摘要 |
It has now been discovered that p53 is a potent inhibitor of angiogenesis and arteriogensis. Inhibition of p53 stimulates angiogenesis, arteriogenesis and improves perfusion in limbs. Therefore, methods are provided for treating diabetic-induced ischemia in a subject in need thereof comprising locally administering a therapeutically effective amount of one or more p53 molecule inhibitors or analogs and derivatives thereof to a site of ischemic tissue in the subject. Methods are provided for improving limb perfusion in a subject in need thereof comprising locally administering a therapeutically effective amount one or more p53 inhibitors together with a therapeutic agent or separately from the therapeutic agent to cells of a limb of a subject in need thereof. Methods are also provided for improving ischemia-induced angiogenesis and arteriogenesis in method of improving ischemia-induced angiogenesis in tissue of a limb comprising administering a therapeutically effective amount one or more p53 inhibitors individually or in combination with another therapeutic to a subject in need thereof. |
申请公布号 |
US2015224088(A1) |
申请公布日期 |
2015.08.13 |
申请号 |
US201514617149 |
申请日期 |
2015.02.09 |
申请人 |
Sarkar Rajabrata;Hoofnagle Mark;Mukhopadhyay Subhradip |
发明人 |
Sarkar Rajabrata;Hoofnagle Mark;Mukhopadhyay Subhradip |
分类号 |
A61K31/428;A61K45/06 |
主分类号 |
A61K31/428 |
代理机构 |
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代理人 |
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主权项 |
1. A method for treating diabetic-induced ischemia in a subject in need thereof comprising locally administering a therapeutically effective amount of one or more p53 molecule inhibitors or analogs and derivatives thereof to a site of ischemic tissue in the subject. |
地址 |
Ellicott City MD US |