发明名称 |
FORMULATIONS AND METHODS FOR TARGETED OCULAR DELIVERY OF THERAPEUTIC AGENTS |
摘要 |
Formulations, systems, and methods of administration are provided for preferential targeted delivery of drug to ocular tissue. In embodiments, the formulation may include a non-Newtonian fluid that facilitates targeted localization or preferential spreading of the fluid formulation in the ocular tissue. The fluid formulation may be administered to an eye of a patient by inserting a microneedle into the eye at an insertion site, and infusing a volume of a fluid formulation through the microneedle into the suprachoroidal space of the eye at the insertion site over a first period. During the first period, the fluid formulation may be distributed over a first region which is less than about 10% of the suprachoroidal space, and during the second period subsequent to the first period the drug formulation may be distributed over a second region which is greater than about 20% of the suprachoroidal space. |
申请公布号 |
WO2015095772(A3) |
申请公布日期 |
2015.08.13 |
申请号 |
WO2014US71623 |
申请日期 |
2014.12.19 |
申请人 |
EMORY UNIVERSITY;GEORGIA TECH RESEARCH CORPORATION |
发明人 |
PRAUSNITZ, MARK R.;KIM, YOO CHUN;EDELHAUSER, HENRY F. |
分类号 |
A61K9/00;A61K31/498;A61K31/5575;A61K39/395;A61K47/36;A61K47/38;A61P27/02;A61P27/06 |
主分类号 |
A61K9/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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