METHOD OF PREDICTING A PREDISPOSITION TO QT PROLONGATION

摘要

The present invention describes an association between genetic polymorphisms in the ABCC2 gene and a predisposition to prolongation of the QT interval, and provides related methods for the prediction of such a predisposition, the administration of QT interval-prolonging compounds to individuals having such a predisposition, and determining whether a compound is capable of inducing QT prolongation.

主权项

1. A method of administering to an individual a compound capable of prolonging the individual's QT interval, the method comprising:
determining at least a portion of an individual's ABCC2 gene sequence; and in the case that a portion of the individual's ABCC2 gene sequence is associated with an increased risk of QT prolongation, administering to the individual a quantity of the compound less than would be administered to an individual having a ABCC2 gene sequence not associated with an increased risk of QT prolongation.