| 摘要 |
The present invention relates to a gastric retentive tablet composition comprising: (1) coated particles consisting of a drug and an amino methacrylate copolymer, and (2) an excipient, wherein the ingredients are blended together, and then compressed into a gastric retentive tablet. Thus, the coated particles and the excipient are evenly distributed in the tablet. The excipient is selected from a group consisting of a retarding agent, a binder, a filler, a chelating agent, a diluent, a disintegrant, a lubricant, a colorant, a solubilizing agent, or a mixture thereof. |
| 主权项 |
1. A gastric retentive tablet composition comprising coated particles and an excipient, wherein each coated particle consists of one core and one coat, wherein the core consists of a drug, wherein the core does not contain an excipient, wherein the coat consists of EUDRAGIT® E (amino methacrylate copolymer-NF), and wherein the drug is selected from the group consisting of sorafenib tosylate, dasatinib and a mixture thereof. |
