发明名称 |
FINGOLIMOD HYDROCHLORIDE PROCESS |
摘要 |
A process for preparation of diethyl 2-acetamido-2-(4-octyl phenyl)ethyl malonate (III), a key intermediate of fingolimod hydrochloride comprising reaction of 2-(4- octylphenyl)ethyl iodide (IV) with diethyl acetamido malonate in presence of a base and an iodinating agent and in an organic solvent. The compound of formula (III) thus obtained provided fingolimod hydrochloride (la) having associated impurities below the regulatory limits. |
申请公布号 |
WO2015092809(A3) |
申请公布日期 |
2015.08.13 |
申请号 |
WO2014IN00720 |
申请日期 |
2014.11.14 |
申请人 |
EMCURE PHARMACEUTICALS LIMITED |
发明人 |
GURJAR MUKUND KESHAV;TRIPATHY NARENDRA KUMAR;NEELAKANDAN KALIAPERUMAL;PANCHABHAI PRASAD PANDURANG;SRINIVAS NANDALA;BALASUBRAMANIAN PRABHAKARAN;BUCHUDE SANDIP BAJABA;MUGALE BALAJI RAM;AHIRRAO PRAVIN PRABHAKAR;MEHTA SAMIT SATISH |
分类号 |
C07C213/02;C07C215/30 |
主分类号 |
C07C213/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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