| 发明名称 |
PROCESS FOR PREPARING (1S)-1-PHENYL-3,4-DIHYDRO-2(1H)-ISOQUINOLINE-CARBOXYLATE |
| 摘要 |
A process for preparation of (1S)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate (Formula I), comprising reacting (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinoline (Formula II) with carbon dioxide and an alkylating agent R-LG in the presence of a base to obtain the compound of Formula I in an organic solvent.;;In Formula I and II, R is an alkyl or a substituted alkyl; LG is a leaving group. |
| 申请公布号 |
US2015225348(A1) |
申请公布日期 |
2015.08.13 |
| 申请号 |
US201514690282 |
申请日期 |
2015.04.17 |
| 申请人 |
Shanghai Jingxin Biomedical Co., Ltd. ;Shangyu Jingxin Pharmaceutical Co., Ltd. |
发明人 |
Huang Yue;ZHENG Fei |
| 分类号 |
C07D217/06 |
主分类号 |
C07D217/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A process for preparing (1s)-1-phenyl-3,4-dihydro-2(1H)-isoquinoline-carboxylate, comprising
reacting (1S)-1-phenyl-3,4-dihydro-2(1H)isoquinoline (Formula II) with carbon dioxide and an alkylating agent R-LG in presence of a base to obtain the compound of Formula I in an organic solvent: wherein R-LG is an alkylating agent. |
| 地址 |
Shanghai CN |
